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Article

Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).

The Journal of pharmacology and experimental therapeutics - 1 Mar 2009

Yee Sook Wah, Shima James E, Hesselson Stephanie, Nguyen Loan, De Val Sarah, Lafond Rachel J, Kawamoto Michiko, Johns Susan J, Stryke Doug, Kwok Pui-Yan, Ferrin Thomas E, Black Brian L, Gurwitz David, Ahituv Nadav, Giacomini Kathleen M

Abstract excerpt

The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. We identified genetic variation in the basal promoter region of CNT2 and characterized the function of the variants. We screened DNA from an ethnically diverse population and identified five basal promoter variants in CNT2....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Transport Proteins

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Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 19098160
DOI: 10.1124/jpet.108.147207
PMCID: PMC2682268

Genes

SLC28A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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