Article
Identification of functional promoter haplotypes of human concentrative nucleoside transporter 2, hCNT2 (SLC28A2).
Drug metabolism and pharmacokinetics - 1 Jan 2009
Li Linghui, Koo Seok Hwee, Hong Ivan Hee Kean, Lee Edmund Jon Deoon
Abstract excerpt
The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs. To determine if single nucleotide polymorphisms (SNPs) in the promoter region of hCNT2 affect gene expression, we examined approximately 1 kb upstream the hCNT2 transcription start site. Ninety Chinese samples were screened and seven...
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