Article
Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).
The pharmacogenomics journal - 1 Jan 2005
Badagnani I, Chan W, Castro R A, Brett C M, Huang C C, Stryke D, Kawamoto M, Johns S J, Ferrin T E, Carlson E J, Burchard E G, Giacomini K M
Abstract excerpt
The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs. As a first step toward understanding the genetic basis for interindividual differences in the disposition and response to antileukemic nucleoside analogs, we examined the genetic and functional...
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