Article
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
PloS one - 9 Sept 2009
Hesselson Stephanie E, Matsson Pär, Shima James E, Fukushima Hisayo, Yee Sook Wah, Kobayashi Yuya, Gow Jason M, Ha Connie, Ma Benjamin, Poon Annie, Johns Susan J, Stryke Doug, Castro Richard A, Tahara Harunobu, Choi Ji Ha, Chen Ligong, Picard Nicolas, Sjödin Elin, Roelofs Maarke J E, Ferrin Thomas E, Myers Richard, Kroetz Deanna L, Kwok Pui-Yan, Giacomini Kathleen M
Abstract excerpt
Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promoter regions of transporter genes contribute to observed variation in drug response. A total of 579 polymorphisms were identified in the proximal promoters (-250 to +50...
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