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Article

Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).

The Journal of pharmacology and experimental therapeutics - 1 Apr 2009

Tahara Harunobu, Yee Sook Wah, Urban Thomas J, Hesselson Stephanie, Castro Richard A, Kawamoto Michiko, Stryke Doug, Johns Susan J, Ferrin Thomas E, Kwok Pui-Yan, Giacomini Kathleen M

Abstract excerpt

The organic cation/ergothioneine transporter OCTN1 (SLC22A4) and the high-affinity carnitine transporter OCTN2 (SLC22A5), play an important role in the disposition of xenobiotics and endogenous compounds. Here, we analyzed the sequence of the proximal promoter regions of OCTN1 and OCTN2 in four ethnic groups and determined the effects of the identified genetic variants on transcriptional activities and mRNA...

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Source

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Identifiers

PMID: 19141711
DOI: 10.1124/jpet.108.146449
PMCID: PMC2670604

Genes

SLC22A4
SLC22A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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