Article
The genetic epidemiology of multiple sclerosis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Oct 1999
Compston A
Abstract excerpt
Epidemiological studies have implicated an interplay between genetic and environmental factors in the aetiology of multiple sclerosis (MS). There is a familial recurrence rate of approximately 15%. Meta-analysis of the recurrence risk shows that the rate is highest overall for siblings, then parents and children, with lower rates in second- and third-degree relatives. Recurrence is highest for monozygotic twins....
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