Article
In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.
Molecular genetics and metabolism - 1 Mar 2009
Clément Karine, Le Stunff Catherine, Meirhaeghe Aline, Dechartres Agnès, Ferrieres Jean, Basdevant Arnaud, Boitard Christian, Amouyel Philippe, Bougnères Pierre
Abstract excerpt
We recently reported that rs361072, a promoter C/T variant of p110beta, the catalytic subunit of PI3-kinase, was associated with a protection from insulin resistance (IR) in Caucasian adolescents in proportion of their body mass. We tested if this cis-regulatory QTL is associated with IR and type 2 diabetes in 7885 middle-aged obese and non-obese adults of European ancestry. We genotyped rs361072 in 1139...
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