Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.

doi:10.2337/db07-1273

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Article

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.

Diabetes - 1 Feb 2008

Le Stunff Catherine, Dechartres Agnès, Mariot Virginie, Lotton Chantal, Trainor Cecelia, Miraglia Del Giudice Emanuele, Meyre David, Bieche Ivan, Laurendeau Ingrid, Froguel Philippe, Zelenika Diana, Fallin Dani, Lathrop Mark, Roméo Paul-Henri, Bougnères Pierre

Abstract excerpt

OBJECTIVE: In search of functional polymorphisms associated with the genetics of insulin resistance, we studied a variant in the promoter of PIK3CB, the gene coding for the catalytic p110beta subunit of phosphatidylinositol (PI) 3-kinase, a major effector of insulin action. RESEARCH DESIGN AND METHODS: The rs361072 C/T variant was selected among single nucleotide polymorphisms of the PIK3CB region because we...

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PMID: 17977952
DOI: 10.2337/db07-1273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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