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PIK3R1 gene polymorphisms are associated with type 2 diabetes and related features in the Turkish population.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jul 2018

Karadoğan Abdullah Hakan, Arikoglu Hilal, Göktürk Fatma, İşçioğlu Funda, İpekçi Süleyman Hilmi

Abstract excerpt

BACKGROUND: The phosphatidylinositol 3-kinase p85 alpha regulatory subunit 1 gene (PIK3R1) encodes the PIK3R1 protein, which plays a direct role in insulin signaling. PIK3R1 (p85 regulatory subunit) connects firmly with the p110 catalytic subunit, and together these proteins form the phosphatidylinositol 3-kinase (PI3K) protein. PI3K is a key protein in the Akt signaling pathway, which regulates cell survival,...

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PMID: 29893513
DOI: 10.17219/acem/68985

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