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A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.

Diabetes - 1 Jul 2003

Muller Yunhua Li, Bogardus Clifton, Beamer Brock A, Shuldiner Alan R, Baier Leslie J

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARgamma)-2 is a member of the nuclear hormone receptor superfamily that is expressed predominantly in adipocytes and is thought to have a role in energy homeostasis, adipogenesis, and insulin sensitivity. A functional single nucleotide polymorphism (SNP) that predicts a proline to alanine substitution (Pro12Ala) within the coding region of this gene has...

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Indians, North American

Receptors, Cytoplasmic and Nuclear

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PMID: 12829658
DOI: 10.2337/diabetes.52.7.1864

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A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.PMID 12829658Read ↗

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