Article
A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.
The Journal of clinical endocrinology and metabolism - 1 Jan 2008
Le Stunff Catherine, Dechartres Agnès, Miraglia Del Giudice Emanuele, Froguel Philippe, Bougnères Pierre
Abstract excerpt
OBJECTIVE: Severe juvenile obesity causes metabolic and cardiovascular complications in adulthood. The catalytic p110beta subunit of phosphatidyl-inositol-3 kinase is a major effector of insulin action. We studied the p110beta gene as a candidate gene for association with insulin resistance (IR) and fasting glycemia in severely obese children. METHODS: We conducted an association study in 580 severely obese...
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