Article
Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels.
Journal of diabetes research - 1 Jan 2015
Soyal Selma M, Felder Thomas, Auer Simon, Oberkofler Hannes, Iglseder Bernhard, Paulweber Bernhard, Dossena Silvia, Nofziger Charity, Paulmichl Markus, Esterbauer Harald, Krempler Franz, Patsch Wolfgang
Abstract excerpt
The genomic region ~500 kb upstream of IRS1 has been implicated in insulin resistance, type 2 diabetes, adverse lipid profile, and cardiovascular risk. To gain further insight into this chromosomal region, we typed four SNPs in a cross-sectional cohort and subjects with type 2 diabetes recruited from the same geographic region. From 16 possible haplotypes, 6 haplotypes with frequencies >0.01 were observed. We...
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