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Article

Identification of genomic regions contributing to etoposide-induced cytotoxicity.

Human genetics - 1 Mar 2009

Bleibel Wasim K, Duan Shiwei, Huang R Stephanie, Kistner Emily O, Shukla Sunita J, Wu Xiaolin, Badner Judith A, Dolan M Eileen

Abstract excerpt

Etoposide is routinely used in combination-based chemotherapy for testicular cancer and small-cell lung cancer; however, myelosuppression, therapy-related leukemia and neurotoxicity limit its utility. To determine the genetic contribution to cellular sensitivity to etoposide, we evaluated cell growth inhibition in Centre d' Etude du Polymorphisme Humain lymphoblastoid cell lines from 24 multi-generational...

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Source

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Identifiers

PMID: 19089452
DOI: 10.1007/s00439-008-0607-4
PMCID: PMC2714550

Genes

PRMT7
UVRAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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