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Pharmacogenomic Characterization of US FDA-approved Cytotoxic Drugs

1 Oct 2011

Abstract excerpt

AIMS: Individualization of cancer chemotherapy based on the patient's genetic makeup holds promise for reducing side effects and improving efficacy. However, the relative contribution of genetics to drug response is unknown. MATERIALS & METHODS: In this study, we investigated the cytotoxic effect of 29 commonly prescribed chemotherapeutic agents from diverse drug classes on 125 lymphoblastoid cell lines derived...

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Carcinogens and Genotoxicity Assessment
Lung Cancer Treatments and Mutations
Pharmacogenetics and Drug Metabolism

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22008047
DOI: 10.2217/pgs.11.92

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