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Article

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.

Journal of medicinal chemistry - 7 Sept 2006

Kinzel Olaf, Fattori Daniela, Muraglia Ester, Gallinari Paola, Nardi Maria Chiara, Paolini Chantal, Roscilli Giuseppe, Toniatti Carlo, Gonzalez Paz Odalys, Laufer Ralph, Lahm Armin, Tramontano Anna, Cortese Riccardo, De Francesco Raffaele, Ciliberto Gennaro, Koch Uwe

Abstract excerpt

A strategy to obtain a fully orthogonal estrogen-receptor-based gene switch responsive to molecules with acceptable pharmacological properties is presented. From a series of tetrahydrofluorenones active on the wild-type estrogen receptor (ER) an inactive analogue is chosen as a new lead compound....

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Source

Identifiers

PMID: 16942012
DOI: 10.1021/jm060516e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16942012-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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