Article

Evolverator: An engineered yeast system to drive rapid continuous <i>in vivo</i> evolution of proteins

2024-09-01

Abstract excerpt

Continuous in vivo evolution of non-essential proteins requires an engineered link between target protein and host cell fitness, which is difficult to establish and vulnerable to escape mutations. We systematically designed and tested Saccharomyces cerevisiae gene circuits guided by quantitative mathematical models that predicted circuit, organism, and population behavior. We identified four generalizable design...

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Literature Corpus work: e62958b4-ba0b-576e-9499-cd7de3e6a947
DOI: 10.1101/2024.09.01.610536

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