The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

doi:10.1084/jem.174.3.525

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Article

The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

The Journal of experimental medicine - 1 Sept 1991

Friedman D F, Cho E A, Goldman J, Carmack C E, Besa E C, Hardy R R, Silberstein L E

Abstract excerpt

To study the association of autoimmunity and human B cell neoplasia, we have established a model of a B cell lymphoma which expresses a pathogenic autoantibody of defined specificity. The Ig VH gene expressed in this neoplasm was analyzed longitudinally using clinical specimens taken from the splenic lymphoma (S) at diagnosis and from lymph node relapses 3 and 4 yr later (N3 and N4). Southern analysis and...

Topics

Amino Acid Sequence
Anemia, Hemolytic, Autoimmune
Autoantigens
Base Sequence
Blotting, Southern
Clone Cells
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Idiotypes

Lymphoma, B-Cell

Molecular Sequence Data

Mutation

Oligonucleotides

Polymerase Chain Reaction

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 1908508
DOI: 10.1084/jem.174.3.525
PMCID: PMC2118944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1908508-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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