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Article

Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes.

British journal of haematology - 1 Mar 1994

Zhu D, Hawkins R E, Hamblin T J, Stevenson F K

Abstract excerpt

The variable region genes used to encode the immunoglobulin expressed by tumour cells of a patient with follicular lymphoma have been identified and sequenced. Initially, a lymph node biopsy was analysed and revealed usage of VH and V kappa genes which had numerous substitutions as compared with the closest germ line genes. The pattern of mutations in VH was consistent with a role for positive selection by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8043433
DOI: 10.1111/j.1365-2141.1994.tb04780.x

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