Article
Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes.
British journal of haematology - 1 Mar 1994
Zhu D, Hawkins R E, Hamblin T J, Stevenson F K
Abstract excerpt
The variable region genes used to encode the immunoglobulin expressed by tumour cells of a patient with follicular lymphoma have been identified and sequenced. Initially, a lymph node biopsy was analysed and revealed usage of VH and V kappa genes which had numerous substitutions as compared with the closest germ line genes. The pattern of mutations in VH was consistent with a role for positive selection by...
Topics
- Amino Acid Sequence
- Antigens, Neoplasm
- Antigens, Surface
- Base Sequence
- Embryonal Carcinoma Stem Cells
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region