Article
Idiotypic variation in a human B lymphoma cell line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1990
Berinstein N, Campbell M J, Lam K, Carswell C, Levy S, Levy R
Abstract excerpt
The Ig Id of a B cell lymphoma serves as a distinct marker of the malignant clone and thus as a tumor-specific target for antibody therapy. Somatic variation of the Ig genes expressed by B cell tumors can lead to loss of reactivity with anti-Id antibodies and escape of tumors from the therapeutic...
Topics
- Antibodies, Anti-Idiotypic
- B-Lymphocytes
- Blotting, Southern
- Cell Separation
- Clone Cells
- Flow Cytometry
- Gene Rearrangement, B-Lymphocyte
- Humans
- Immunoglobulin Idiotypes
- Lymphoma
- Mutation
- Tumor Cells, Cultured