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Article

Idiotypic variation in a human B lymphoma cell line.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1990

Berinstein N, Campbell M J, Lam K, Carswell C, Levy S, Levy R

Abstract excerpt

The Ig Id of a B cell lymphoma serves as a distinct marker of the malignant clone and thus as a tumor-specific target for antibody therapy. Somatic variation of the Ig genes expressed by B cell tumors can lead to loss of reactivity with anti-Id antibodies and escape of tumors from the therapeutic effects of such antibodies. In our study, we have used anti-Id antibodies to screen for variants within a cell line...

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Identifiers

PMID: 2295809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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