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Article

Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).

Journal of clinical immunology - 1 Jul 2004

Abraham Roshini S, Geyer Susan M, Ramírez-Alvarado Marina, Price-Troska Tammy L, Gertz Morie A, Fonseca Rafael

Abstract excerpt

Light chain amyloidosis (AL) is a protein folding disorder with an underlying B cell neoplasia where the monoclonal immunoglobulin light chains (LCs) produced from insoluble amyloid fibrils. The deposition of these fibrillar aggregates in vital organs causes severe organ dysfunction over time and is associated with high mortality. We have identified the postgerminal center status of the B cell clone by evaluating...

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Identifiers

PMID: 15163890
DOI: 10.1023/B:JOCI.0000029113.68758.9f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).PMID 15163890Read ↗

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