Article
Differential in situ expansion and gene expression of CD4+ and CD8+ tumor-infiltrating lymphocytes following adoptive immunotherapy in a murine tumor model system.
European journal of immunology - 1 Aug 1991
Evans R, Duffy T M, Kamdar S J
Abstract excerpt
In previous reports, we demonstrated that adoptively transferred T cells homed to the tumor site (among other sites) and that amplification of immune responses occurred in situ leading to the generation of cytotoxic CD8+ tumor-infiltrating lymphocytes (TIL) and macrophages. The present report extends these findings and shows that following adoptive immunotherapy (AIT) of mice bearing the immunogenic transplanted...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Gene Expression
- Immunotherapy, Adoptive
- Interferon-gamma
- Interleukin-2
- Lymphocytes, Tumor-Infiltrating
- Mice