Article
In vitro cytolytic activity of lymphocytes from tumor-draining lymph nodes is associated with increased numbers of CD8+ cells and increased cytokine production.
The Journal of surgical research - 1 Jan 1995
Holley D, Freeman J, Hamby L, Mattingly C, McGrath P C
Abstract excerpt
A murine footpad tumor model was used to determine the cytotoxic activity, tumor specificity, phenotypic profile, and cytokine production of stimulated cells from draining lymph nodes (DLN). Popliteal DLN from 5-day-old P-815 footpad tumors were stimulated with 10(-7) M phorbol 12, 13-dibutyrate...
Topics
- Animals
- CD4-CD8 Ratio
- CD8-Positive T-Lymphocytes
- Cytokines
- Female
- Foot
- Lymph Nodes
- Mice
- Mice, Inbred DBA
- Neoplasms, Experimental
- Phenotype
- T-Lymphocytes, Cytotoxic