Article
Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes.
Journal of neuro-oncology - 1 Mar 1997
Baldwin N G, Rice C D, Tuttle T M, Bear H D, Hirsch J I, Merchant R E
Abstract excerpt
It has been shown that adoptive immunotherapy can be curative for established malignant tumors. The key to this treatment lies in obtaining sufficient numbers of lymphocytes which are sensitized to recognize tumor antigens and carry out immunological reactions to destroy tumor cells. Reported her...
Topics
- Animals
- Antigens, Neoplasm
- Brain Neoplasms
- Cell Communication
- Female
- Glioma
- Immunotherapy, Adoptive
- Interleukin-2
- Lymph Nodes
- Phenotype
- Rats
- Rats, Inbred F344
- Signal Transduction
- T-Lymphocytes
- Tumor Cells, Cultured