Article
Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice.
International journal of cancer - 1 Sept 2000
Klugewitz K, Scheffold A, Radbruch A, Hamann A
Abstract excerpt
In the murine kidney sarcoma, vaccination with the tumor-specific large T antigen induces protective immunity against the tumor. Immunity is dependent both on CD8(+) cytotoxic T cells and on CD4(+) T-helper cells. We analyzed whether the cytokine phenotype of induced CD4(+) T-effector cells might determine whether or not the tumor is successfully rejected. By intracytoplasmic staining of CD4(+) cells,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.