Article
Adenovirus-mediated interleukin-2 production by tumors induces growth of cytotoxic tumor-infiltrating lymphocytes against human renal cell carcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 May 1998
Mulders P, Tso C L, Pang S, Kaboo R, McBride W H, Hinkel A, Gitlitz B, Dannull J, Figlin R, Belldegrun A
Abstract excerpt
Combination therapy with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes (TILs) demonstrates significant clinical activity in patients with metastatic renal cell carcinoma (RCC). To investigate whether local delivery of IL-2 via gene transfer is capable of improving the potency and effica...
Topics
- Adenoviridae
- Carcinoma, Renal Cell
- Cells, Cultured
- Cytotoxicity, Immunologic
- Flow Cytometry
- Gene Expression
- Genetic Vectors
- Humans
- Immunotherapy, Adoptive
- Interleukin-2
- Kidney Neoplasms
- Lymphocytes, Tumor-Infiltrating
- Phenotype
- Polymerase Chain Reaction