Patterns of cytokine release of unselected and CD8+ selected renal cell carcinoma tumor-infiltrating lymphocytes (TIL). Evidence for enhanced specific killing of tumor necrosis factor-secreting/IL-6 nonsecreting TIL in vitro and correlation with complete response in vivo.

doi:10.1006/clin.1994.1137

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Article

Patterns of cytokine release of unselected and CD8+ selected renal cell carcinoma tumor-infiltrating lymphocytes (TIL). Evidence for enhanced specific killing of tumor necrosis factor-secreting/IL-6 nonsecreting TIL in vitro and correlation with complete response in vivo.

Clinical immunology and immunopathology - 1 Aug 1994

Steger G G, Pierce W C, Figlin R, Czernin J, Kaboo R, DeKernion J B, Okarma T, Belldegrun A

Abstract excerpt

Murine systems have demonstrated improved anti-tumor efficacy when tumor-infiltrating lymphocytes (TIL) are combined with interleukin-2 (IL-2). One goal of human adoptive immunotherapy is to identify and expand TIL with specific activity against autologous tumor. In this study we attempted to iso...

Topics

CD8 Antigens
Carcinoma, Renal Cell
Cells, Cultured
Cytokines
Cytotoxicity, Immunologic
Humans
Immunophenotyping
Immunotherapy, Adoptive
Interleukin-2
Interleukin-6
Kidney Neoplasms
Lymphocytes, Tumor-Infiltrating
Macrophage-1 Antigen

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Outcome Assessment, Health Care

Phenotype

T-Lymphocyte Subsets

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 8050198
DOI: 10.1006/clin.1994.1137

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8050198-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.