Article
In vivo distribution and cytokine gene expression by enriched mouse LAK effector cells.
Biotherapy (Dordrecht, Netherlands) - 1 Jan 1991
Futami H, Pilaro A M, Gruys M E, Back T C, Young H A, Wiltrout R H
Abstract excerpt
Lymphokine activated killer (LAK) cells administered in combination with interleukin 2 (IL2) can mediate antitumor activity in tumor-bearing mice and advanced cancer patients. Relatively little is known about the mechanism by which adoptively transferred LAK cells plus IL2 mediate these antitumor...
Topics
- Animals
- Blotting, Northern
- Cytokines
- Cytotoxicity Tests, Immunologic
- Gene Expression
- Idoxuridine
- Indium Radioisotopes
- Interferon-gamma
- Killer Cells, Lymphokine-Activated
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phenotype
- RNA, Messenger
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha