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Article

Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.

EMBO reports - 1 Jan 2009

Zhao Bo, Benson Erica K, Qiao Ruifang, Wang Xing, Kim Sunchin, Manfredi James J, Lee Sam W, Aaronson Stuart A

Abstract excerpt

Ku80 is important in the repair of DNA double-strand breaks by its essential function in non-homologous end-joining. The absence of Ku80 causes the accumulation of DNA damage and leads to premature ageing in mice. We showed that mouse embryonic fibroblasts (MEFs) from ku80(-/-) mice senesced rapidly with elevated levels of p53 and p21. Deletion of p21 delayed the early senescence phenotype in ku80(-/-) MEFs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19079133
DOI: 10.1038/embor.2008.220
PMCID: PMC2613205

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