Article
Deletion of Ku86 causes early onset of senescence in mice.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 1999
Vogel H, Lim D S, Karsenty G, Finegold M, Hasty P
Abstract excerpt
DNA double-strand breaks formed during the assembly of antigen receptors or after exposure to ionizing radiation are repaired by proteins important for nonhomologous end joining that include Ku86, Ku70, DNA-PK(CS), Xrcc4, and DNA ligase IV. Here we show that ku86-mutant mice, compared with control littermates, prematurely exhibited age-specific changes characteristic of senescence that include osteopenia,...
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