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Article

Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.

Mechanisms of ageing and development - 1 Jan 2000

Holcomb Valerie B, Vogel Hannes, Hasty Paul

Abstract excerpt

Animal models of premature aging are often defective for DNA repair. Ku80-mutant mice are disabled for nonhomologous end joining; a pathway that repairs both spontaneous DNA double-strand breaks (DSBs) and induced DNA DSBs generated by the action of a complex composed of Rag-1 and Rag-2 (Rag). Ra...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17928034
DOI: 10.1016/j.mad.2007.08.006
PMCID: PMC2692937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17928034-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.PMID 17928034Read ↗

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