Article
Editing disease-associated autoantibodies.
Immunity - 1 Jan 1997
Chen C, Prak E L, Weigert M
Abstract excerpt
We have generated site-directed transgenic mice whose transgenes code for anti-DNA antibodies. These antibodies are representative of the lupus-associated anti-DNAs seen in mouse models of autoimmunity and human SLE, and have the usual characteristics of pathogenic autoantibodies. As conventional...
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