Article
The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status.
European journal of immunology - 1 Apr 2002
Yachimovich Nurit, Mostoslavsky Gustavo, Yarkoni Yuval, Verbovetski Inna, Eilat Dan
Abstract excerpt
Anti-DNA knock-in mice serve as models for studying B cell tolerance mechanisms to a ubiquitous antigen. We have constructed six strains of double transgenic (C57BL/6xBALB/c)F1 mice, each expressing an unmutated or somatically mutated anti-DNA heavy (H) chain, combined with one of three different light (L) chains, namely V(kappa)1-J(kappa)1, V(kappa)4-J(kappa)4 and V(kappa)8-J(kappa)5. In vitro analysis of the...
Topics
- Alleles
- Animals
- Antibodies, Antinuclear
- Antibody Affinity
- Antibody Specificity
- Autoantigens
- Bone Marrow Cells
- Clonal Anergy
- Crosses, Genetic
- DNA
- DNA, Single-Stranded
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain