Article
Analysis of B cell receptor production and rearrangement. Part I. Light chain rearrangement.
Seminars in immunology - 1 Jun 2002
Louzoun Yoram, Friedman Tzivia, Luning Prak Eline, Litwin Sam, Weigert Martin
Abstract excerpt
A probabilistic model of allelic exclusion fails to explain the status of receptor genes and the receptor phenotype of most B cells. A large proportion of B cells have incompletely rearranged H and/or L chain genes (e.g. kappa0/kappa+) and most B cells express only one receptor. These properties seem to require deterministic features of B cell development such as special mechanisms that stop rearrangement....
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