Article
ATOM: a powerful gene-based association test by combining optimally weighted markers.
Bioinformatics (Oxford, England) - 15 Feb 2009
Li Mingyao, Wang Kai, Grant Struan F A, Hakonarson Hakon, Li Chun
Abstract excerpt
BACKGROUND: Large-scale candidate-gene and genome-wide association studies genotype multiple SNPs within or surrounding a gene, including both tag and functional SNPs. The immense amount of data generated in these studies poses new challenges to analysis. One particularly challenging yet important question is how to best use all genetic information to test whether a gene or a region is associated with the trait...
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