Detecting association of rare variants by testing an optimally weighted combination of variants for quantitative traits in general families.

Abstract excerpt

Although next-generation sequencing technology allows sequencing the whole genome of large groups of individuals, the development of powerful statistical methods for rare variant association studies is still underway. Even though many statistical methods have been developed for mapping rare variants, most of these methods are for unrelated individuals only, whereas family data have been shown to improve power to...

Topics

• Algorithms
• Computer Simulation
• Family
• Gene Frequency
• Genetic Association Studies
• Genetic Variation
• Genotype
• Humans
• Models, Genetic
• Pedigree
• Phenotype