Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.

The Journal of biological chemistry - 6 Feb 2009

Ren Yong, Jiang Houbo, Yang Fang, Nakaso Kazuhiro, Feng Jian

Abstract excerpt

Mitogen-activated protein kinases, originally known as microtubule-associated protein (MAP) kinases, are activated in response to a variety of stimuli. Here we report that microtubule-depolymerizing agents such as colchicine or nocodazole induced strong activation of MAP kinases including JNK, ERK, and p38. This effect was markedly attenuated by parkin, whose mutations are linked to Parkinson disease (PD). Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colchicine
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insecticides

Share to Mesencephalon

Share to Nocodazole

Share to Rotenone

Share to Tubulin Modulators

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 19074146
DOI: 10.1074/jbc.M806245200
PMCID: PMC2635057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.PMID 19074146Read ↗

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.Semantic proximity Read ↗

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.Semantic proximity Read ↗

Parkin stabilizes microtubules through strong binding mediated by three independent domains.Semantic proximity Read ↗

Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.Semantic proximity Read ↗

Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts.Semantic proximity Read ↗

Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons.Semantic proximity Read ↗

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule‐dependent mechanismSemantic proximity Read ↗

NF-kappaB promotes survival during mitotic cell cycle arrest.Semantic proximity Read ↗

Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1.Semantic proximity Read ↗

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.Semantic proximity Read ↗

Parkin is associated with actin filaments in neuronal and nonneural cellsSemantic proximity Read ↗

Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.