Article
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.
Journal of neurochemistry - 1 May 2006
Casarejos M J, Menéndez J, Solano R M, Rodríguez-Navarro J A, García de Yébenes J, Mena M A
Abstract excerpt
Parkinson's disease is a neurodegenerative disorder which is in most cases of unknown etiology. Mutations of the Park-2 gene are the most frequent cause of familial parkinsonism and parkin knockout (PK-KO) mice have abnormalities that resemble the clinical syndrome. We investigated the interaction of genetic and environmental factors, treating midbrain neuronal cultures from PK-KO and wild-type (WT) mice with...
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