Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2005

Latchoumycandane Calivarathan, Anantharam Vellareddy, Kitazawa Masashi, Yang Yongjie, Kanthasamy Arthi, Kanthasamy Anumantha G

Abstract excerpt

Manganese (Mn) exposure causes manganism, a neurological disorder similar to Parkinson's disease. However, the cellular mechanism by which Mn induces dopaminergic neuronal cell death remains unclear. In the present study, we sought to investigate the key downstream apoptotic cell signaling events that contribute to Mn-induced cell death in mesencephalic dopaminergic neuronal (N27) cells. Mn exposure induced a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Cytochromes c

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Dopamine

Share to Manganese

Share to Mesencephalon

Share to Protein Kinase C

Share to Protein Kinase C-delta

Source

Identifiers

PMID: 15608081
DOI: 10.1124/jpet.104.078469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.PMID 15608081Read ↗

Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.Semantic proximity Read ↗

Methamphetamine-induced neuronal apoptosis involves the activation of multiple death pathways. ReviewSemantic proximity Read ↗

Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damageSemantic proximity Read ↗

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.Semantic proximity Read ↗

6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression.Semantic proximity Read ↗

Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.Semantic proximity Read ↗

Pathophysiology of manganese-associated neurotoxicity.Semantic proximity Read ↗

Asbestos-induced apoptosis is protein kinase C delta-dependent.Semantic proximity Read ↗

Tumor necrosis factor receptor‐1‐induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitisSemantic proximity Read ↗

Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide.Semantic proximity Read ↗

α-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cellsSemantic proximity Read ↗

MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.