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Article

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2003

Ren Yong, Zhao Jinghui, Feng Jian

Abstract excerpt

In addition to inhibiting the mitochondrial respiratory chain, toxins known to cause Parkinson's disease (PD), such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and rotenone, also strongly depolymerize microtubules and increase tubulin degradation. Microtubules are polymers of tubulin alpha/beta heterodimers, whose correct folding requires coordinated actions of cellular chaperonins and cofactors. Misfolded...

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Identifiers

PMID: 12716939
PMCID: PMC1876717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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