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Article

Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons.

Stem cells (Dayton, Ohio) - 1 Jan 2015

Ren Yong, Jiang Houbo, Hu Zhixing, Fan Kevin, Wang Jun, Janoschka Stephen, Wang Xiaomin, Ge Shaoyu, Feng Jian

Abstract excerpt

Parkinson's disease (PD) is characterized by the degeneration of nigral dopaminergic (DA) neurons and non-DA neurons in many parts of the brain. Mutations of parkin, an E3 ubiquitin ligase that strongly binds to microtubules, are the most frequent cause of recessively inherited PD. The lack of robust PD phenotype in parkin knockout mice suggests a unique vulnerability of human neurons to parkin mutations. Here,...

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Identifiers

PMID: 25332110
DOI: 10.1002/stem.1854
PMCID: PMC4429885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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