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Article

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule‐dependent mechanism

6 Jan 2009

Abstract excerpt

Parkin is an E3 ubiquitin ligase encoded by the Parkin gene (also called PARK2, located at 6q25.2-q27) and is involved in the pathogenesis of Parkinson's disease and the development of cancer. Recently, Parkin has been demonstrated to interact with the microtubule cytoskeleton. However, the biological implication of the Parkin-microtubule axis has been poorly explored. In this study, we report for the first time...

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Identifiers

PMID: 19214989
DOI: 10.1002/path.2512

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Related research

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Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule‐dependent mechanismPMID 19214989Read ↗

miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibitionSemantic proximity Read ↗

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Semantic proximity Read ↗

PSMD8 Promotes Breast Cancer Progression and Attenuates Paclitaxel Sensitivity by Regulating the Expression of KIF10Semantic proximity Read ↗

Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells*Semantic proximity Read ↗

Microtubule Dynamics Deregulation Induces Apoptosis in Human Urothelial Bladder Cancer Cells via a p53-independent PathwaySemantic proximity Read ↗

Microtubule‐Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer ChemotherapySemantic proximity Read ↗

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.Semantic proximity Read ↗

The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activitySemantic proximity Read ↗

Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.Semantic proximity Read ↗

TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagySemantic proximity Read ↗

Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In VivoSemantic proximity Read ↗

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Semantic proximity Read ↗

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