NF-kappaB promotes survival during mitotic cell cycle arrest.

Abstract excerpt

By activating the mitotic checkpoint, anti-microtubule drugs such as nocodazole cause mammalian cells to arrest in mitosis and then undergo apoptosis. Microtubule depolymerization is rapid and results in the activation of the transcription factor NF-kappaB and induction of NF-kappaB-dependent gene expression. However, the functional consequence of NF-kappaB activation has remained unclear. Evidence has...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Densitometry
• Share to I-kappa B Kinase
• Share to I-kappa B Proteins