Parkin is associated with actin filaments in neuronal and nonneural cells

Abstract excerpt

Inactivating mutations of the gene encoding parkin are responsible for autosomal recessive juvenile parkinsonism (AR-JP). However, little information is known about the function and distribution of parkin. We generated antibodies to two different peptides of parkin. By Western blot analysis and immunohistochemistry, we found that parkin is a 50-kd protein that is expressed in neuronal processes and cytoplasm of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurological diseases and metabolism
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments