Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.

The Journal of biological chemistry - 13 Feb 2009

Chiang Y Jeffrey, Jordan Martha S, Horai Reiko, Schwartzberg Pamela L, Koretzky Gary A, Hodes Richard J

Abstract excerpt

A signaling pathway involving ZAP-70, LAT, and SLP76 has been regarded as essential for receptor-driven T cell development and activation. Consistent with this model, mice deficient in SLP76 have a complete block at the double negative 3 stage of T cell development. Recently, however, it has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oncogene Proteins
Share to Lymphocyte Activation
Share to Phosphoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-cbl

Share to Proto-Oncogene Proteins c-vav

Share to Receptors, Antigen, T-Cell

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 19074136
DOI: 10.1074/jbc.M808679200
PMCID: PMC2640981

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19074136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.PMID 19074136Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.Semantic proximity Read ↗

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Semantic proximity Read ↗

Conditional deletion of SLP‐76 in mature T cells abrogates peripheral immune responsesSemantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in miceSemantic proximity Read ↗

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.Semantic proximity Read ↗

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.Semantic proximity Read ↗

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read ↗

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.Semantic proximity Read ↗

The role of SLP-76 and LAT in lymphocyte development.Semantic proximity Read ↗

Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.