Article
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.
The Journal of experimental medicine - 17 Feb 2003
Thien Christine B F, Scaife Robin M, Papadimitriou John M, Murphy Maria A, Bowtell David D L, Langdon Wallace Y
Abstract excerpt
The unique tyrosine kinase binding (TKB) domain of Cbl targets phosphorylated tyrosines on activated protein tyrosine kinases (PTKs); this targeting is considered essential for Cbl proteins to negatively regulate PTKs. Here, a loss-of-function mutation (G304E) in the c-Cbl TKB domain, first identified in Caenorhabditis elegans, was introduced into a mouse and its effects in thymocytes and T cells were studied. In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.