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Article

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

Immunity - 1 Mar 2008

Jordan Martha S, Smith Jennifer E, Burns Jeremy C, Austin Jessica-Elise T, Nichols Kim E, Aschenbrenner Anna C, Koretzky Gary A

Abstract excerpt

The adaptor protein SLP76 directs signaling downstream of the T cell receptor (TCR) and is essential for thymocyte development. SLP76 contains three N-terminal tyrosines that are critical for its function. To define the role of these residues in thymocyte development, we generated two lines of "knock-in" mice, one expressing a mutation in tyrosine 145 (Y145F) and a second harboring two point mutations at...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18342008
DOI: 10.1016/j.immuni.2008.01.010
PMCID: PMC2323515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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