Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

Immunity - 1 Mar 2008

Jordan Martha S, Smith Jennifer E, Burns Jeremy C, Austin Jessica-Elise T, Nichols Kim E, Aschenbrenner Anna C, Koretzky Gary A

Abstract excerpt

The adaptor protein SLP76 directs signaling downstream of the T cell receptor (TCR) and is essential for thymocyte development. SLP76 contains three N-terminal tyrosines that are critical for its function. To define the role of these residues in thymocyte development, we generated two lines of "k...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Immunoblotting
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Phosphoproteins

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 18342008
DOI: 10.1016/j.immuni.2008.01.010
PMCID: PMC2323515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18342008-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.PMID 18342008Read ↗

Functional hierarchy of the N-terminal tyrosines of SLP-76.Semantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

The role of SLP-76 and LAT in lymphocyte development.Semantic proximity Read ↗

Conditional deletion of SLP‐76 in mature T cells abrogates peripheral immune responsesSemantic proximity Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.Semantic proximity Read ↗

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read ↗

Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.