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Article

Loss of Rap1GAP in papillary thyroid cancer.

The Journal of clinical endocrinology and metabolism - 1 Mar 2009

Nellore Anoma, Paziana Karolina, Ma Changqing, Tsygankova Oxana M, Wang Yan, Puttaswamy Kanchan, Iqbal Ammarah U, Franks Susanna R, Lv Yu, Troxel Andrea B, Feldman Michael D, Meinkoth Judy L, Brose Marcia S

Abstract excerpt

CONTEXT: Rap1 GTPase-activating protein (GAP) regulates the activity of Rap1, a putative oncogene. We previously reported Rap1GAP was highly expressed in normal human thyroid cells and decreased in five papillary thyroid carcinomas (PTCs). OBJECTIVES: To confirm the significance of these findings, we analyzed Rap1GAP expression in a larger set of benign tumors (adenomas and hyperplastic nodules) and PTCs. We...

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Identifiers

PMID: 19066305
DOI: 10.1210/jc.2008-1042
PMCID: PMC2681278

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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