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Article

RAC1b overexpression in papillary thyroid carcinoma: a role to unravel

12 Mar 2013

Abstract excerpt

CONTEXT: The BRAF V600E mutation is the most frequent genetic alteration in papillary thyroid carcinoma (PTC). In colorectal cancer, BRAF V600E was described to functionally cooperate with RAC1b, a hyperactive splice variant of the small GTPase RAC1, to sustain cell survival. This interplay has never been investigated in PTCs. OBJECTIVE: We aimed to analyze the expression of RAC1b in PTC and correlate its...

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Share to Protein Kinase Regulation and GTPase Signaling
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Identifiers

PMID: 23482591
DOI: 10.1530/eje-12-0960

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