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Article

The role of microRNA genes in papillary thyroid carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

He Huiling, Jazdzewski Krystian, Li Wei, Liyanarachchi Sandya, Nagy Rebecca, Volinia Stefano, Calin George A, Liu Chang-Gong, Franssila Kaarle, Suster Saul, Kloos Richard T, Croce Carlo M, de la Chapelle Albert

Abstract excerpt

Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs (miRNAs) are transcriptionally up-regulated in PTC tumors compared with unaffected thyroid tissue. A set of five miRNAs, including the three most up-regulated ones (miR-221, -222, and -146), distinguished unequivocally between PTC and normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16365291
DOI: 10.1073/pnas.0509603102
PMCID: PMC1323209

Genes

KIT
BRAF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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