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Article

Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors.

Cancer research - 15 Feb 2010

Zuo Hui, Gandhi Manoj, Edreira Martin M, Hochbaum Daniel, Nimgaonkar Vishwajit L, Zhang Ping, Dipaola James, Evdokimova Viktoria, Altschuler Daniel L, Nikiforov Yuri E

Abstract excerpt

Thyroid cancer is the most common type of endocrine malignancy, encompassing tumors with various levels of invasive growth and aggressiveness. Rap1GAP, a Rap1 GTPase-activating protein, inhibits the RAS superfamily protein Rap1 by facilitating hydrolysis of GTP to GDP. In this study, we analyzed...

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Source

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Identifiers

PMID: 20124489
DOI: 10.1158/0008-5472.CAN-09-2812
PMCID: PMC2822891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20124489-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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